Chitosan-based Maillard self-reaction products: Formation, characterization, antioxidant and antimicrobial potential

In this work, new chitosan derivatives (CS1-CS6) were obtained by short-term hydrothermal treatment. The formation of occurred through two simultaneous processes: hydrolysis and Maillard self-reaction. synthesized chitosan-based self-reaction products characterized physical measurements spectroscopic methods (viscometry, UV–Vis, FTIR, 1H NMR, TGA XRD). results showed that treatment solutions leads to a significant decrease (from ∼ 66500 up 20150 Da) in the viscosity-average molecular weight polymer. It has been shown antiradical activity CS1-CS6 was 2-5 times higher comparison with unmodified (1.42 µg ascorbic acid equivalents/mg). enhanced (R value ≥ 4-5) antimicrobial CS1-CS5 against gram-negative gram-positive bacteria including thermophilic highly heat-resistant Geobacillus stearothermophilus demonstrated.